黄瑾      教授/博导

联系方式：

电话: 021-64253681

办公室：实验18楼625

E-mail: huangjin@ecust.edu.cn

招生专业：药学一级学科 （博士/学硕/专硕）, 制药工程与技术（专硕）

本课题组热忱欢迎有志于药理学、化学生物学、结构生物学及新药开发领域研究的优秀学生加入！！

欢迎关注“药物化学生物学”课题组文献和实验技能分享微信公众号

个人简介：

beat365·体育官网教授，本科毕业于四川大学，于南京大学获博士学位，现为beat365·体育官网教授，博士生导师。作为项目负责人，已完成和正在承担共计10余项国家和省部课题，包括来自国家自然科学委、教育部、上海市科委和上海市教委等研究计划。为Med. Res. Rev.、J. Med. Chem.、ACS Med. Chem. Lett.等知名期刊的审稿人，担任上海市科委及国家自然科学基金等省部级项目评审专家、114产学研专家。

奖励：

研究方向与学生培养：

本课题组以分子药理学为基础，开展高效药物筛选平台构建，新药物作用靶标确证及抗肿瘤药物发现相关研究，具体工作涵盖药理学、药物筛选、药物化学生物学、结构生物学等方面的研究，研究对象从蛋白质、基因、细菌、酵母、动物细胞直到活体动物都可能涉及，欢迎追求卓越的同学加盟本实验室。

经过三年或五年的培养，学生在分子生物学（分子克隆构建、信号通路分析）、结构生物学（蛋白表达纯化、蛋白结晶及三维结构解析）、光谱测试分析（紫外可见吸收光谱、稳态与瞬态荧光光谱等）、生物显微成像（共聚焦显微成像、超分辨成像技术）、化学生物学（荧光生物标记、药物先导化合物发现）等方面有较好的培训。

研究成果发表在Angew. Chem. Int. Ed.、Haematologica、Oncogene、J. Med. Chem.等本领域高影响期刊。

课题组培养的多个博士、硕士研究生曾获国家奖学金、上海市优秀毕业生、中国药理学会青年药理学家奖等荣誉称号。

正在开展的一些研究包括：

1、特异性靶向筛选平台构建：

针对筛选体系不稳定或无法有效靶向的药物靶点开展高效、特异性筛选体系构建。

更快的速度、更简单的操作、更具有特异性筛选方法、更稳定的测试方法可高效助力靶向药物发现，现代药物的发现离不开高效地从数以万计的结构各异的化合物中准确找到具有药物活性的小分子药物候选物。

本课题组开发的部分高效筛选方法

2、基于结构的药物发现：

靶向药物作用的一大特点为直接作用于药物靶点，通过调控药物靶标的生物学活性实现对疾病的治疗。基于结构的药物发现通过解析活性小分子与靶标的相互作用位点及关键作用基团，为后续的药物设计及结构改造提供了可靠的理论依据。

本课题组已获得的部分研究成果

3、肿瘤调控新通路的发现

疾病如何产生？疾病如何治疗？哪种药物的治疗会更为有效？疾病发生发展是一个负责的过程，受体内多种酶和蛋白的调控，而药物是否有效不仅取决于疾病产生的原因，也和患者的个体差异高度相关。

对疾病发生发展的核心事件进行剖析，明确调控疾病恶性进程的关键通路及关键靶蛋白/靶基因，有助于指导疾病治疗的临床用药，有效缓解疾病恶性进程。本课题组主要关注恶性肿瘤，通过分子生物学、细胞生物学、化学生物学及动物活体评价等手段研究肿瘤调控新通路及开展靶向新药物候选物发现的相关研究。

本课题组开展的肿瘤调控新通路研究

代表性论文：

1.        Weiwei Huang, Yi Huang, Jiayan Cui, Yuhang Wu, Fuli Zhu, Jin Huang*, Lei Ma*. Design and synthesis of Osthole-based compounds as potential Nrf2 agonists. Bioorg Med Chem Lett. 2022 Apr 1; 61: 128547.

2.        Ji-An Chen, Hui Ma, Zehui Liu, Jinlong Tian, Sisi Lu, Wenqing Fang, Shuyin Ze, Weiqiang Lu, Qiong Xie*, Jin Huang*, Yonghui Wang*. Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. J Med Chem. 2022 Jan 13; 65(1): 592-615.

3.        Zengrui Wu, Hui Ma, Zehui Liu, Lulu Zheng, Zhuohang Yu, Shuying Cao, Wenqing Fang, Lili Wu, Weihua Li, Guixia Liu, Jin Huang*, Yun Tang*. wSDTNBI: a novel network-based inference method for virtual screening. Chem Sci. 2021 Dec 21; 13(4): 1060-1079.

4.        Xi Liu, Qian Hu, Wanyan Wang, Hui Ma, Jiaqian Pu, Jiayan Cui, Ting Gong, Yu Wu, Weiqiang Lu*, Jin Huang*. A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer. Biochem Pharmacol. 2021 Jun; 188: 114583.

5.        Wanyan Wang, Jiayan Cui, Hui Ma, Weiqiang Lu, Jin Huang*. Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine. Front Oncol. 2021 May 28; 11: 684961.

6.        Wanyan Wang, Yu Wu, Si Chen, Xi Liu, Jiacheng He, Shuyi Wang, Weiqiang Lu*, Yong Tang*, Jin Huang*. Shikonin is a novel and selective IMPDH2 inhibitor that target triple-negative breast cancer.Phytother Res. 2021 Jan; 5(1): 63-476.

7.        Zehui Liu, Qian Hu, Wanyan Wang, Sisi Lu, Dang Wu, Shuyin Ze, Jiacheng He, Ying Huang, Wuyan Chen, Yechun Xu, Weiqiang Lu*, Jin Huang*. Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase. Biochem Pharmacol (Biochemical Pharmacology), 2020 Jul;177:114000

8.        Zehui Liu, Wanyan Wang, Tingyu Huang, Cunfang Wang, Ying Huang*, Yong Tang*, Jin Huang*. CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer's disease. PLoS One, 2019 Sep 23, 14(9): e0222757.

9.        Xueyuan Wu, Mingbo Wang, Yaqian Wang, Mengyin Li, Yilun Ying, Jin Huang*, Yitao Long*. Precise Construction and Tuning of an Aerolysin Single-Biomolecule Interface for Single-Molecule Sensing. CCS Chemistry. 2019 Aug; 1(3): 81-89.

10.    Zhonghong Zhu, Qian Hu, Huiling Pan, Yuexing Zhang, Haibing Xu, Mohamedally Kurmoo, Jin Huang*, Ming-Hua Zeng*. Tracking the multiple-step formation of an iron(III) complex and its application in photodynamic therapy for breast cancer. Science China-chemistry. 2019 Jun, 62(6): 719-726.

11.    Dang Wu, Wanyan Wang, Wuyan Chen, Fulin Lian, Li Lang, Ying Huang, Yechun Xu, Naixia Zhang, Yinbin Chen, Mingyao Liu, Ruth Nussinov, Feixiong Cheng*, Weiqiang Lu*, Jin Huang*. Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. Haematologica. 2018 Sep, 103(9): 1472-1483.

12.    Li Lang, Qian Hu, Jingyuan Wang, Zehui Liu, Jin Huang*, Weiqiang Lu*, Ying Huang*. Coptisine, a natural alkaloid from Coptidis Rhizoma, inhibits plasmodium falciparum dihydroorotate dehydrogenase. Chem Biol Drug Des (Chemical Biology & Drug Design). 2018 Jul, 92(1):1324-1332.

13.    Weiqiang Lu, Feixiong Cheng, Wenzhong Yan, Xi Li, Xue Yao, Wenqiang Song, Mingyao Liu, Xu Shen, Hualiang Jiang, Jing Chen, Jian Li*, Jin Huang*.Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA. Oncogene. 2017, Aug 17, 36(33): 4719-4731.

14.    Weiqiang Lu, Xue Yao, Ping Ouyang, Ningning Dong, Dang Wu, Xingwu Jiang, Zengrui Wu, Chen Zhang, Zhongyu Xu, Yun Tang, Shien Zou, Mingyao Liu, Jian Li, Minghua Zeng, Ping Lin, Feixiong Cheng*, Jin Huang*. Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis. J Med Chem (Journal of Medicinal Chemistry). 2017 Mar 9; 60(5): 1817-1828.

15.    Jingyuan Wang, Xue Yao, Jin Huang*. New Tricks for Human Farnesyltransferase Inhibitor: Cancer and Beyond. MedChemComm, 2017, 8, 841-852.

16.    Zengrui Wu, Weiqiang Lu, Dang Wu, Anqi Luo, Hanping Bian, Jie Li, Weihua Li, Guixia Liu, Jin Huang*, Feixiong Cheng*, Yun Tang*. In silico prediction of chemical mechanism-of-action via an improved network-based inference method. Br J Pharmacol (British Journal of Pharmacology). 2016 Sep 20;173:3372-3385.

17.    Li Lang, Ningning Dong, Deyan Wu, Xue Yao, Weiqiang Lu*, Chen Zhang, Ping Ouyang, Jin Zhu, Yun Tang, Wei Wang, Jian Li*, Jin Huang*. 2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors. J Enzyme Inhib Med Chem (Journal of Enzyme Inhibition and Medicinal Chemistry). 2016 Sep 2; 31(sup4): 98-105.

18.    Minghua Zeng*, Zheng Yin, Zehui Liu, Haibing Xu, Yingchun Feng, Yueqiao Hu, Lixian Chang, Yuexing Zhang, Jin Huang*, Mohamedally Kurmoo. Assembly of a Highly Stable Luminescent Zn5 Cluster and Application to Bio-Imaging. Angew Chem Int Ed Engl (Angewandte Chemie International Edition). 2016 Sep 12; 55(38): 11407-11411.

19.    Xue Yao, Dang Wu, Ningning Dong, Ping Ouyang, Jiaqian Pu, Qian Hu, Jingyuan Wang, Weiqiang Lu*, Jin Huang*. Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Int J Mol Sci (International Journal of Molecular Sciences). 2016 Jul 25; 17(8). pii: E1199.

20.    Huiling Pan, Qian Hu, Jingyuan Wang, Zehui Liu, Dang Wu, Weiqiang Lu*, Jin Huang*. Myricetin is a novel inhibitor of human inosine 5'-monophosphate dehydrogenase with anti-leukemia activity. Biochem Biophys Res Commun (Biochemical and Biophysical Research Communications). 2016 Sep 2; 477(4): 915-922.