钱旭红，博士、院士、国家自然科学基金咨询委员(化学部)、英国皇家化学会会士、德国洪堡基金会大使科学家。

     男，1962年生于江苏宝应。1978.9 进入华东化工学院(现beat365·体育官网)石油化工系，1982.7, 获基本有机化工学士学位，1982.9 华东化工学院(现beat365·体育官网)精细化工系研究生，1985.4获硕士学位, 1988．7beat365·体育官网获工学博士学位；1989.8-1990.8美国德克萨斯州拉玛大学Research Associate; 1990.9-1991.12德国维尔茨堡大学洪堡基金（AvH）博士后。1988-1992.4beat365·体育官网讲师；1992.8-1994.7副教授；1994.8－至今，教授；1995.12博士生导师； 1986-1987;beat365·体育官网精细化工系党总支副书记；1992.8－1995.4先后任beat365·体育官网精细化工学科主任、药物化工研究所所长;1995.5-7,国家高级教育行政学院学员;1995.9-1996.2任beat365·体育官网校长助理、1996.3-2000.10任副校长。2002.1-2010.1 上海市化学生物学重点实验室主任(兼)；2003.3-2006 国家南方农药创制中心(上海) 主任(兼)。2004.7- , beat365·体育官网校长。2007. 4-, 中国化工学会副理事长；2007-2009，亚洲及太平洋化工联盟主席。

      获1992霍英东基金会高校优秀青年教师奖; 1995全国优秀教师；1996国务院政府特殊津贴；1998 中国青年科技奖；1999第六届上海十大科技精英. 作为第一完成人，获得1998、2002、2003教育部科技进步一等奖、2008上海市自然科学一等奖、2008国家科技进步二等奖、2010上海市自然科学二等奖。2011年当选中国工程院院士。

    钱旭红教授的研究方向是生物有机化学与工程。其研究工作主要为由杂环芳烃和有机氟衍生的绿色化学农药、生物功能染料的化学生物学及工程。涉及农药先导、荧光传感器、抗癌先导、人工核酸酶、细胞激活剂的芳香杂环分子设计、合成、构效关系及生物应用。

 研究方向

1.染料的化学生物学 

 其研究主要集中在荧光传感器与新机制抗癌先导，包括以下内容：

荧光传感器：由萘、萘酰亚胺、香豆素、氟硼吡咯、聚合物衍生的高选择性过渡及重金属离子(汞、铜、锌、银、钯等)荧光传感器；某些阴离子、酶的荧光传感器；以及其它的荧光探针、荧光标记。

抗癌先导：由硫化合物、噻类芳香杂环、羰酰亚胺、萘酰亚胺、萘内酰胺、苯并吲哚酚嗪、吖啶、苊萘醌、苊萘吡咯羰腈、酞菁等衍生的抗癌试剂，BCL蛋白与细胞调亡剂，拓扑异构酶抑制剂，光动力治疗剂，色素的药物化学(抗肿瘤先导、DNA嵌入剂、细胞调亡剂)。

CHEM. COMMUN.-2010-6418:"Alive" dyes as fluorescent sensors: fluorophore, mechanism, receptor and images in living cells

CHEM. COMMUN.-2010-7121: Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe

CHEM. COMMUN.-2010-2772:A design concept of planar conjugated ladder oligomers of perylene bisimides and efficient synthetic strategy via regioselective photocyclization

CHEM. COMMUN. -2008-6339: Highly Sensitive and Selective Pd2+ Sensor of Naphthalimide Derivative Based on Complexation with Alkynes and Thio-heterocycle

CHEM. COMMUN. -2008-4141: Multiple Molecular Logic Functions and Molecular Calculation Facilitated by Surfactant with its Versatility

CHEM. COMMUN. -2008-777: Bulky 4-tritylphenylethynyl substituted boradiazaindacene: Pure red emission, relatively large Stokes shift and inhibition of self-quenching 

CHEM. COMMUN. -2008-1780: A Design Concept of Long Wavelength Fluorescent Analogs of Rhodamine Dyes: Replacement of Oxygen with Silicon Atom

CHEM. COMMUN. -2006-109: Two regioisomeric and exclusively selective Hg(II) sensor molecules composed of a naphthalimide fluorophore and an o-phenylenediamine derived triamide receptor  

CHEM. COMMUN. -2005-239: A new class of long-wavelength fluorophores: strong red fluorescence, convenient synthesis and easy derivation  

CHEM. COMMUN. -2001-2656: Intramolecular aromatic 1,5-hydrogen transfer in preparation of oxacyclic naphthalic anhydride via unusual Pschorr cyclisation

J. AM. CHEM. SOC.-2010-601:Zn2+-Triggered Amide Tautomerization Produces a Highly Zn2+-Selective, Cell-Permeable, and Ratiometric Fluorescent Sensor
  J. AM. CHEM. SOC. -2008-16160: A highly sensitive and selective OFF-ON fluorescent sensor for cadmium in aqueous solution and living cell

J. AM. CHEM. SOC. -2004-2272: A highly selective and sensitive fluorescent chemosensor for Hg2+ in neutral buffer aqueous solution  

ANGEW. CHEM. INTl. ED. -2008-8025: A Ratiometric Fluorescent Probe Based on FRET for Imaging Hg2+ in Living Cells

CHEM. EUR. J.-2010-5013:A Simple Assay for the Fluorometric Detection of Lithium Ions in Aqueous Solution

CHEM. EUR. J.-2010-104:Cross-Reactive Sensor Arrays for the Detection of Peptides in Aqueous Solution by Fluorescence Spectroscopy

CHEM. EUR. J. -2009-319:Selective and Sensitive Chromo- and Fluorogenic Dual Detection of Anionic Surfactants in Water Based on a Pair of "On-Off-On" Fluorescent Sensors

CHEM. EUR. J. -2007-7543: Micelle-Induced Versatile Performance of Amphiphilic Intramolecular Charge-Transfer Fluorescent Molecular Sensors

ORG. LETT. -2011-264:Highly Selective and Sensitive Near-Infrared Fluorescent Sensors for Cadmium in Aqueous Solution

ORG. LETT.-2009-2808:Efficient Synthesis of Regioisomerically Pure Bis(trifluoromethyl)-Substituted 3,4,9,10-Perylene Tetracarboxylic Bis(benzimidazole)

ORG. LETT. -2008-473: Ratiometric and Water-Soluble Fluorescent Zinc Sensor of Carboxamidoquinoline with an Alkoxyethylamino Chain as Receptor

ORG. LETT.  -2008-29: Highly Efficient Energy Transfer in the Light Harvesting System Composed of Three Kinds of Boron-Dipyrromethene Derivatives

ORG. LETT. -2008-633: Isomeric Boron-Fluorine Complexes with Donor-Acceptor Architecture: Strong Solid/Liquid Fluorescence and Large Stokes Shift

ORG. LETT. -2008-633: 2,3,6,7-Tetraamino-9,9-bis(2-ethyl- hexyl)fluorene: new multifunctional monomer for soluble ladder-type conjugated molecules and polymers

ORG. LETT.-2006-3721: A series of polyamide receptor based PET fluorescent sensor molecules: Positively cooperative Hg2+ ion binding with high sensitivity 

ORG. LETT. -2005-3029: Colorimetric and ratiometric fluorescent chemosensor with a large red-shift in emission: Cu(II)-only sensing by deprotonation of secondary amines as receptor conjugated to naphthalimide fluorophore

ORG. LETT. -2005-889: Ratiometric and selective fluorescent sensor for Cu-II based on internal charge transfer (ICT) 

ORG. LETT. -2004-2757: Novel fluorescent pH sensors based on intramolecular hydrogen bonding ability of naphthalimide  

J. ORG. CHEM.-2010-3007: Core-Perfluoroalkylated Perylene Diimides and Naphthalene Diimides: Versatile Synthesis, Solubility, Electrochemistry, and Optical Properties

J. ORG. CHEM. -2009-2167: A Rhodamine-Based Hg2+ Sensor with High Selectivity and Sensitivity in Aqueous Solution: A NS2-Containing Receptor

J. ORG. CHEM.  -2008-1571: Novel Fluorescent Fluorine-Boron Complexes: Synthesis, Crystal Structure, Photoluminescence, and Electrochemistry Properties

J. ORG. CHEM. -2007-3554: Ratiometric and highly selective fluorescent sensor for cadmium under physiological pH range: A new strategy to discriminate cadmium from zinc

J. ORG. CHEM. -2006-4308: Detecting Hg2+ ions with an ICT fluorescent sensor molecule: Remarkable emission spectra shift and unique selectivity 

MOL. CANCER RES.-2010-1619:B1, a Novel Amonafide Analogue, Overcomes the Resistance Conferred by Bcl-2 in Human Promyelocytic Leukemia HL60 Cells
  MOL. CANCER THER. -2007-484: R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II  

J. MED. CHEM.-2010-2589:A New Class of Naphthalimide-Based Antitumor Agents That Inhibit Topoisomerase II and Induce Lysosomal Membrane Permeabilization and Apoptosis
J． MED. CHEM. -2009-763: A Gold(I) Phosphine Complex Containing a Naphthalimide Ligand Functions as a TrxR Inhibiting Antiproliferative Agent and Angiogenesis Inhibitor

KIDNEY INTERNATIONAL -2004-2279: Fluorescent imaging of acute mercuric chloride exposure on cultured human kidney tubular epithelial cells 

CHEM. RES. TOX.-2009-483:DNA Double Helix Unwinding Triggers Transcription Block-Dependent Apoptosis: A Semiquantitative Probe of the Response of ATM, RNAPII, and p53 to Two DNA Intercalators
  CHEM. RES. TOXIC. -2005-1814: Visible study of mercuric ion and its conjugate in living cells of mammals and plants 

CHEMBIOCHEM -2007-113: Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents 

CANCER LETTERS-2009-193:M-2-A induces apoptosis and G(2)-M arrest via inhibiting PI3 K/Akt pathway in HL60 cells
  NEOPLASIA-2009-1226: Naphthalimides Induce G(2) Arrest Through the ATM-Activated Chk2-Executed Pathway in HCT116 Cells
  EUR. J. MED. CHEM.-2009-4674: Novel naphthalimide derivatives as potential apoptosis-inducing agents: Design, synthesis and biological evaluation

BIOORG. MED. CHEM. LETT. -2006-1562: Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor 

BIOORG. MED. CHEM. LETT. -2005-5909: Novel synthetic isoquinolino[5,4-ab]phenazines: Inhibition toward topoisomerase I, antitumor and DNA photo-cleaving activities 

BIOORG. MED. CHEM. LETT. -2005-4864: Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: Effects of intercalation, side chains, and substituent groups

BIOORG. MED. CHEM. LETT. -2005-4864: Synthesis, antitumor evaluation and DNA photocleaving activity of novel methylthiazonaphthalimides with aminoalkyl side chains

BIOORG. MED. CHEM. LETT. -2005-1139: Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: intercalation and photocleavage to DNA (SS)

BIOORG. MED. CHEM. LETT. -2003-5427: Novel naphthalimide hydroperoxide photonucleases: The role of thiocyclic-fused area and the difference in spectra, photochemistry and photobiological activity

BIOORG. MED. CHEM.-2010-3279:Novel DNA intercalators without basic side chains as efficient antitumor agents: Design, synthesis and evaluation of benzo-[c,d]-indol-malononitrile derivatives

BIOORG. MED. CHEM.-2009-7615 :  Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: Synthesis, cytotoxicity, DNA-binding and cell cycle evaluation
  BIOORG. MED. CHEM.-2009-592: Novel naphthalimide-amino acid conjugates with flexible leucine moiety as side chain: Design, synthesis and potential antitumor activity

BIOORG. MED. CHEM. -2007-1356: Novel antitumor agent family of 1H-benzo[c,d]indol-2-one with flexible basic side chains: Synthesis and biological evaluation

BIOORG. MED. CHEM. -2006-6962：Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: Various DNA binding geometry and interesting antitumor capacity 

BIOORG. MED. CHEM. -2006-4639: Design, synthesis, and antitumor evaluation of novel acenaphtho[1,2-b]pyrrole-carboxylic acid esters with amino chain substitution 

BIOORG. MED. CHEM. -2005-3149: Novel heterocyclic family of phenyl naphthothiazole carboxamides derived from naphthalimides: synthesis, antitumor evaluation, and DNA photocleavage 

BIOORG. MED. CHEM. -2005-1615: Thio-heterocylic naphthalimides with aminoalkyl side chains: novel alternative tools for photodegradation of genomic DNA without impairment on bioactivities of proteins

INT. J. BIO. MACROMOL. -2006-59: Study on the interaction between 4-(2-diethylanuno- ethylamino)-8-oxo-8H- acenaphtho  [1,2-b]pyrrole- 9-carbonitrile and DNA by molecular spectra 

TETRAHEDRON LETT.-2009-22:Novel naphthalimide derivatives with near-infrared emission: synthesis via photochemical cycloaromatization, fluorescence in solvents and living cell

TETRAHEDRON LETT. -2005-6289: A proton sponge-based fluorescent switch

TETRAHEDRON LETT. -2004-3969: A novel chromatism switcher with double receptors selectively for Ag+ in neutral aqueous solution: 4,5-diaminoalkeneamino-N-alkyl-1,8-naphthalimides  

TETRAHEDRON LETT. -2003-2087: Novel highly efficient fluoroionophores with a peri-effect and strong electron-donating receptors: TICT-promoted PET and signaling response to transition metal cations with low background emission

TETRAHEDRON LETT. -2003-795: Promoting effects of the hydroxymethyl group on the fluorescent signaling recognition of anions by thioureas  

TETRAHEDRON LETT. -2002-2991: 4-Amino-1,8-dicyanonaphthalene derivatives as novel fluorophore and fluorescence switches: efficient synthesis and fluorescence enhancement induced by transition metal ions and protons

TETRAHEDRON LETT. -2002-2995: Synthesis and properties of benzothioxanthene dicarboximide hydroperoxide: an efficient 'time-resolved' DNA photocleaver with long-wavelength

TETRAHEDRON LETT. -2001-6175: N-aroyloxynaphthalimides as novel highly efficient DNA photocleavers: substituent effects  

TETRAHEDRON LETT. -2000-7711: Novel and highly efficient DNA photocleavers: hydroperoxides of heterocyclic-fused naphthalimides  

TETRAHEDRON-2009-8099: Long-wavelength boradiazaindacene derivatives with two-photon absorption activity and strong emission: versatile candidates for biological imaging applications
  TETRAHEDRON -2006-10117: Exploiting the deprotonation mechanism for the design of ratiometric and colorimetric Zn2+ fluorescent chemosensor with a large red-shift in emission 
  TETRAHEDRON -2005-11895:Novel DNA bis-intercalators of isoquinolino[4,5-bc]acridines: design, synthesis and evaluation of cytotoxic activity

TETRAHEDRON -2005-11264: Versatile acenaphtho[1,2-b]pyrrol-carbonitriles as a new family of heterocycles: diverse Snar(H)H reactions, cytotoxicity and spectral behavior 

TETRAHEDRON -2005-8717: Synthesis, antitumor and DNA photocleaving activities of novel naphthalene carboxamides: effects of different thio-heterocyclic rings and aminoalkyl side chains

TETRAHEDRON -2005-6634: Synthesis of thiazo- or thiadiazo- naphthalene carboxamides via mercuric intermediates and their antitumor and DNA photocleavage activities  

NEW J. CHEM. -2008-472: Chromogenic and fluorescent chemodosimeter for fluoride ion based on

novel anion-catalyzed intramolecular hydrogen transfer

NEW J. CHEM. -2003-337: A polyamidoamine dendrimer with peripheral 1,8-naphthalimide groups capable of acting as a PET fluorescent sensor for metal cations

NEW J. CHEM. -2002-920: Novel heterogeneous PET fluorescent sensors selective for transition metal ions or protons: polymers regularly labelled with naphthalimide

DYES PIGMENTS-2009-127: Novel perfluoroalkyl phthalocyanine metal derivatives: Synthesis and photodynamic activities
  DYES PIGMENTS -2004-17: Synthesis and peroxidase-staining properties of novel water soluble polyhydroxylalkyl benzidine dyes 

DYES PIGMENTS -2004-9: Benzothioxanthene dyes as fluorescent label for DNA hybridization: synthesis and application

DYES PIGMENTS -2002-247: Synthesis and properties of oligonucleotides containing fluorescent ethenodeoxyadeno sine and ethenodeoxycytidine

DYES PIGMENTS -2001-51: Absorption and fluorescence spectral properties of tetra (fluoroalkoxy) metallophthalocyanines 

DYES PIGMENTS -2001-43: Oxazolonaphthalimides and their hydroperoxides: photophysical and photobiological properties 

J. FLUORINE CHEM. -2002-161: Synthesis and photosensitizing properties of fluoroalkoxyl phthalocyanine metal complexes

J. FLUORINE CHEM. -2000-69: Synthesis of fluorine-containing oxazolonaphthalimide hydroperoxides as DNA photocleavers

J. PHOTOCHEM. PHOTOBIO. A -2010-86: Solvent effects for fluorescence and absorption of tetra (fluoroalkyl) metallophthalocyanines: Fluorocarbon solvent cage
  J. PHOTOCHEM. PHOTOBIO. A -2010-24:Unusual large Stokes shift and solvatochromic fluorophore Synthesis, spectra, and solvent effect of 6-substituted 2,3-naphthalimide
  J. PHOTOCHEM. PHOTOBIO. B -2001-35:Tetra-trifluoroethoxyl zinc phthalocyanine: potential photosensitizer for use in the photodynamic therapy of cancer 

J. PHOTOCHEM. PHOTOBIO. A -2009-181:A pair of regio-isomeric compounds acting as molecular logic gates with different functions
  J. PHOTOCHEM. PHOTOBIO. B -2006-221: Isoquino[4,5-bc]acridines: Design, synthesis and evaluation of DNA binding, anti-tumor and DNA photo-damaging ability 

DALTON TRANSACTIONS-2010-7114:A fluorescent sensor for pyrophosphate based on a Pd(II) complex

DALTON TRANSACTIONS-2010-1316:A thioether-rich crown-based highly selective fluorescent sensor for Hg2+ and Ag+ in aqueous solution

DALTON TRANSACTIONS-2009-1761:A colorimetric sensor for Cu2+ in aqueous solution based on metal ion-induced deprotonation: deprotonation/protonation mediated by Cu2+-ligand interactions

ORG. BIOMOL. CHEM.-2009-129:A red-shift colorimetric and fluorescent sensor for Cu2+ in aqueous solution: unsymmetrical 4,5-diaminonaphthalimide with N-H deprotonation induced by metal ions

J. CHEM. SOC.-PERKIN 2 -2000-715: Interaction of naphthyl heterocycles with DNA: effects of thiono and thio groups 

CHEM. LETT. -2005-696: Novel naphthalimide fluorescent sensors selective for certain proteins on basis of non-covalent interactions between enzyme and inhibitor 

CHINESE CHEM. LETT. -2004-118: Anthracylmethyl benzoazacrown ether as selective fluorescence sensors for Zn2+ 

ANALY. CHIM. ACTA 2009-227: Trace mercury (II) detection and separation in serum and water samples using a reusable bifunctional fluorescent sensor
  CHINESE J. ANAL. CHEM. -2004-837:Studies on the room temperature phosphorescence of halogen naphthalic anhydrides

J. CHEM. TECH. BIOTECH. -2009-1051:  Fluorous biphase oxidation of ethyl benzene and benzyl alcohol catalyzed by perfluoroalkyl phthalocyanine complexes

SCI. CHINA B-CHEM.-2009-771:Highly sensitive and selective ratiometric fluorescent copper sensors: Different binding affinities modulated by three separate side chains of naphthalimide

J. MATER. CHEM. -2010-10755: Ratiometric and reusable fluorescent nanoparticles for Zn2+ and H2PO4- detection in aqueous solution and living cells

J. MATER. CHEM. -2005-2836: A pH-resistant Zn(II) sensor derived from 4-aminonaphthalimide: design, synthesis and intracellular applications

CHEMPHYSCHEM -2008-1891: Molecular Logic Operations Based on Surfactant Nano-aggregates: Premicelle, Micelle and Its Formation Induced by Inorganic Salt

POLYMER -2002-5731: Synthesis and photophysical properties of 1,8-naphthalimide-labelled PAMAM as PET sensors of protons and of transition metal ions

HETEROCYCL. COMMUN. -2003-229: A new class of DNA intercalator and photocleaver: Bis-naphthailimides with bromo and nitro substituents

2.农药的化学与生物学

其研究主要集中在芳香杂环或氟化合物衍生的农药先导，包括以下内容：

昆虫调节剂与杀虫剂先导：针对几丁质合成抑制、蜕皮激动、海藻糖酶抑制、拒食、飞行调控的昆虫生长调节剂与行为调节剂，烟碱受体激动类杀虫剂。  

新杂环化合物：主要有具有农药活性的氟化合物、氟烷氧基化合物、硫化合物、恶二唑、噻二唑、哒嗪酮、新烟碱、环亚胺、二芳酰基肼等。

BIOORG. MED. CHEM. LETT. -2009-332:1,3,4-Oxadiazoline derivatives as novel potential inhibitors targeting chitin biosynthesis: Design, synthesis and biological evaluation
BIOORG. MED. CHEM. LETT. -2008-6513:cis-Nitromethylene neonicotinoids as new nicotinic family: Synthesis, structural diversity, and insecticidal evaluation of hexahydroimidazo[1,2-a]pyridine

BIOORG. MED. CHEM. -2008-7565:1,3,4-Oxadiazole-3(2H)-carboxamide derivatives as potential novel class of monoamine oxidase (MAO) inhibitors: Synthesis, evaluation, and role of urea moiety

EUR. J. MED. CHEM.-2009-2985: Diacylhydrazine derivatives as novel potential chitin biosynthesis inhibitors: Design, synthesis, and structure-activity relationship
EUR. J. MED. CHEM.-2009-2113:Novel 4H-1,3,4-oxadiazin-5(6H)-ones with hydrophobic and long alkyl chains: Design, synthesis, and bioactive diversity on inhibition of monoamine oxidase, chitin biosynthesis and tumor cell

ORG. BIOMOL. CHEM.-2010-2386:A general strategy for construction of a difluoromethyl compound library and its application in synthesis of pseudopeptides bearing a terminal difluoromethyl group

TETRAHEDRON LETT.-2010-4866:K2CO3-assisted one-pot sequential synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates under solvent-free conditions

TETRAHEDRON LETT.-2009-1982:New gem-difluoromethylene-containing isocyanide as a useful building block for the synthesis of difluorinated pseudopeptides via Ugi reaction

TETRAHEDRON-2011-285: Non-catalytic conversion of C-F bonds of gem-difluoromethylene derivatives to C-H bonds with lithium aluminum hydride under room temperature

TETRAHEDRON-2009-10377: One step from nitro to oxime: a convenient preparation of unsaturated oximes by the reduction of the corresponding vinylnitro compounds
TETRAHEDRON -2008-3877:Solvent-Free Ugi Four-Component Condensation: Application to Synthesis of Philanthotoxins-12 Analogues

SYNLETT. -2008-1341: Ytterbium (III) Perfluorooctanoate-catalyzed One-pot Three-component Synthesis of Fully Substituted Pyrazoles under Solvent-free Conditions

SYNLETT. -2008-3058: One-Pot Synthesis of Trifluoromethyl-Containing Pyrazoles via Sequential Yb(PFO)3-Catalyzed Three-Component Reaction and IBX-Mediated Oxidation

J. AGRI. FOOD CHEM.-2010- 2690:Synthesis, Crystal Structure, and Insecticidal Activities of Highly Congested Hexahydroimidazo[1,2-a]pyridine Derivatives: Effect of Conformation on Activities

J. AGRI. FOOD CHEM.-2010- 2696:Divalent and Oxabridged Neonicotinoids Constructed by Dialdehydes and Nitromethylene Analogues of Imidacloprid: Design, Synthesis, Crystal Structure, and Insecticidal Activities
J. AGRI. FOOD CHEM.-2010- 2613:China: Forward to the Green Pesticides via a Basic Research Program

J. AGRI. FOOD CHEM.-2010- 2736:Synthesis and Insecticidal Activity of Heptafluoroisopropyl-Containing Benzoylphenylurea Structures
J. AGRI. FOOD CHEM. -2009-951: Design, Synthesis, and Insecticidal Activities of Novel Analogues of Neonicotinoids: Replacement of Nitromethylene with Nitroconjugated System

J. AGRI. FOOD CHEM. -2007-2288: Synthesis, insecticidal activity, and QSAR of novel nitromethylene neonicotinoids with tetrahydropyridine fixed cis configuration and exo-ring ether modification
J. AGRI. FOOD CHEM. -2006-125: Synthesis and herbicidal activity of novel 3-aminocarbonyl-2-oxazolidinethione derivatives containing a substituted pyridine ring

J. AGRI. FOOD CHEM. -2006-8793: Novel, unnatural benzo-1,2,3-thiadiazole-7-carboxylate elicitors of taxoid biosynthesis

J. AGRI. FOOD CHEM. -2005-3120: Syntheses, antifeedant activity, and QSAR analysis of new oxa(thia)diazolyl 3(2H)-pyridazinones

J. AGRI. FOOD CHEM. -2003-152: Synthesis and Antifeedant Activity of New Oxadiazolyl 3(2H)-Pyridazinones

J. AGRI. FOOD CHEM. -2001-124: Synthesis and Quantitative Structure-Activity Relationships of New 2,5-Disubstituted-1,3,4-oxadiazoles

J. AGRI. FOOD CHEM. -2001-5279: Synthesis and Quantitative Structure-Activity Relationships of Fluorine-Containing 4,4-Dihydroxylmethyl-2-aryl imino- oxazo (thiazo)lidines as Trehalase Inhibitors

J. AGRI. FOOD CHEM. -1999-4415: Quantitative studies on structure-activity relationship of sulfonylurea and benzoylphenylurea type pesticides and their substituents' bioisosterism using synthons' activity contribution

J. AGRI. FOOD CHEM. -1996-1538: Molecular modeling study on the structure-activity relationship of substituted dibenzoyl-1-tert-butylhydrazines and their structural similarity to 20-hydroxyecdysone

PEST MANAGEMENT SCI.-2010-238: Recent progress of highly efficient in vivo biological screening for novel agrochemicals in China
PESTICIDE BIOCHEM. PHYSIOLOGY -2004-42: Photolarvicidal effect of thienyl 1,3,4-thia(oxa)diazoles and their potential DNA photocleavage

ACS SYMPOSIUM SERIES -2005(892)-273: Oxadiazole derivatives as novel insect-growth regulators: Synthesis and structure-bioactivity relationship 

J. FLUORINE CHEM. -2006-182: Synthesis and herbicidal activities of fluorine-containing 3-pyridylmethyl-2- phenyliminothiazolidine derivatives

J. FLUORINE CHEM. -2005-297: Synthesis and fungicidal activity of fluorine-containing phenylimino-thiazolidines derivatives

J. FLUORINE CHEM. -2005-53: Synthesis and biological activities of hydroxyl-protected fluorine-containing 4,4-dihydroxylmethyl-2-aryl-iminothiazolidines 

J. FLUORINE CHEM. -2004-1159: Synthesis and fungicidal activity of fluorine-containing phenylimino-thiazolidines derivatives  

J. FLUORINE CHEM. -2004-1609: Syntheses, structures and bioactivities of fluorine-containing phenylimino-thia(oxa)zolidine derivatives as agricultural bioregulators

J. FLUORINE CHEM. -2003-163: Synthesis and insecticidal activities of novel 2,5-disubstituted 1,3,4-oxadiazoles 

J. FLUORINE CHEM. -2003-51: Synthesis and insecticidal activity of new substituted N-aryl-N’-benzoylthiourea compounds

J. FLUORINE CHEM. -2002-63: Syntheses and insecticidal activity of new 2-(5-(trifluoromethyl)pyridyloxymethyl) -1,3,4-oxadiazoles]  

J. FLUORINE CHEM. -2000-111: Fluorine containing heterocyclic compounds: synthesis of 6-substituted-2-substituted-aryl-1,2,4-triazolo[5,1-b] 1,3,5- thia- diazin-7-one derivatives

J. FLUORINE CHEM. -2000-173: Syntheses and insecticidal activities of novel 2-fluorophenyl-5-aryl/cyclopropyl-1,3,4-oxadiazoles

J. FLUORINE CHEM. -2001-143: Synthesis and biological activities of fluorine-containing N, N’-diphenylcarbamimidothioates 

CHEM. PHYS. LETT. -2003-489: Intramolecular noncovalent force in cyclic amidines: nonbonded interaction between carbon atoms and heteroatoms

PEST. MANAG. SCI. -2003-933: The toxic and anti-feedant activity of 2H-pyridazin-3-one-substituted 1,3,4-oxadiazoles against the armyworm Pseudaletia separata (Walker) and other insects and mite 

CARBOHYDRATE RESEARCH -2001-79: Syntheses and activities as trehalase inhibitors of N-arylglycosylamines derived from fluorinated anilines

CAN. J. CHEM. -2003-272: N'-tert-Butyl-N'-aroyl-N-(alkoxycarbonylmethyl)-N- aroylhydrazines, a novel nonsteroidal ecdysone agonist: syntheses, insecticidal activity, conformational and crystal structure analysis

J. CHEM. RES. -2006- 626: Synthesis and bioactivities of novel neonicotinoids dioxolane compounds 

J. CHEM. RES. -2000-88: The crystal structure of 1-phenyl-3-methyl-5-[2 '-(4 ''-phenylmethoxylphenyl)ethoxyl]pyrazole, a potential insect juvenile hormone mimic

J. CHEM. RES. -1999-66: The crystal structure of N-(5-phenyl-1,3,4-oxadiazol-2-yl)-N '-benzoyl urea, a novel insect-growth regulator

J. CHEM. RES. -1998-478: Crystal structure of 1-(3,5-dichloro-2,4-difluorophenyl)-3- (2,6-difluorobenzoyl)urea, an inhibitor of chitin synthesis

ARKIVOC -2003-141: Synthesis and insecticidal activity of 1,2,4-triazole derivatives

CHINESE CHEM. LETT.  -2004-7: Novel Analogues of -Terthienyl，Thienyl 1，3，4-Thia(oxa)diazoles as Potential Photoactivated Insecticides：Synthesis and Bioactivity

CHEM. LETT. -2001-54: A Novel and Practical Amination of 4,5-Dichloropyridazin-3-ones via Reduction with Hydrazine Hydrate

ORG. PREP. PROCEDURE INTL. -2000-571: A facile synthesis of aryl isothiocyanates from arylamines

MOL. DIVERSITY-2010-501:A mild and efficient synthesis of monofluorinated alpha-lactam pseudopeptides via a novel dehydrofluorination of Ugi products

MONATSH. CHEM.-2010-1117:Design, synthesis, and bioactivity of cyanonitrovinyl neonicotinoids as potential insecticides

SCI. CHINA-CHEM.-2010-1509:An efficient three-component domino synthesis of difluoromethyl-containing 1,4-dihydropyridines under solvent and catalyst free conditions
PHOSPHORUS SULFUR AND SILICON-2009-1825: Novel Heterocyclic Compounds Containing Sulfur: Synthesis and Insecticidal Activity of (2-Chlorothiazol-5-yl)methyl 2-Phenyliminothiazolidines

HETEROATOM CHEM.-2009-418: Design, synthesis, and Evaluation of Unsymmetrical Difluoro-Boron Complexes with Imidazoline as Potential Fungicides
J. COMPUT. CHEM. -2010-586: Novel Dimer Based Descriptors with Solvational Computation for QSAR Study of Oxadiazoylbenzoyl-ureas as Novel Insect-growth Regulators
GREEN CHEM.-2009-1414: A revisit to the Hantzsch reaction: Unexpected products beyond 1,4-dihydropyridines

 3.化学生物技术与工程 
 

其研究主要集中在人工核酸酶、细胞激活剂和生物转化，包括以下方面：

人工核酸酶：由萘酰亚胺、硫杂环衍生的人工光核酸酶，人工核酸水解酶，DNA切断剂；生物制备过程中转基因物质的去除。

细胞激活剂：由茉莉酮酸酯、苯并噻二唑等衍生的细胞激活剂；用于人参、紫杉烷、灵芝的次生代谢物的增产与调控。

生物转化：酵母、植物细胞催化或导致的刚性芳香与杂环化合物的硝基及酮立体选择性还原，化学选择性还原。 

CHEM. COMMUN. -2006-865: Baker's yeast-mediated enantioselective reduction of substituted fluorenones  

CHEM. COMMUN. -2005-2338: A novel strategy for the preparation of arylhydroxylamines: chemoselective reduction of aromatic nitro compounds using bakers' yeast

CHEM. COMMUN. -2004-2339: A novel strategy for the preparation of arylhydroxylamines: chemoselective reduction of aromatic nitro compounds using bakers’ yeast

TETRAHEDRON-ASYMMETRY-2010-825:Preparation of chiral trans-5-substituted-acenaphthene- 1,2-diols by baker's yeast-mediated reduction of 5-substituted-acenaphthylene-1,2-diones
TETRAHEDRON LETT. -2004-1247: Naphthalimide-thiazoles as novel photonucleases: molecular design, synthesis, and evaluation  

APPL. MICROBIO. BIOTECH. -2006-298: Efficient induction of ginsenoside biosynthesis and alteration of ginsenoside heterogeneity in cell cultures of Panax notoginseng by using chemically synthesized 2-hydroxyethyl jasmonate 

APPL. MICROBIO. BIOTECH. -2006-164:  Novel synthetic 2,6-dichloroisonicotinate derivatives as effective elicitors for inducing the biosynthesis of plant secondary metabolites 

APPL. MICROBIO. BIOTECH. -2005-98: A novel synthetic fluoro-containing jasmonate derivative acts as a chemical inducing signal for plant secondary metabolism  

BIOORG. MED. CHEM. LETT. -2005-1769: Novel 2-aminothiazonaphthalimides as visible light activatable photonucleases: effects of intercalation, heterocyclic-fused area and side chains

BIOORG. MED. CHEM. LETT. -2003-3513: Thiadiazole: A new family of intercalative photonuclease with electron transfer and radical mechanisms  

BIOORG. MED. CHEM. LETT. -2004-2665: Highly-efficient DNA photocleavers with long wavelength absorptions: thio-heterocyclic fused naphthalimides containing aminoalkyl side chains

BIOORG. MED. CHEM. LETT. -2004-2335: N-aroyloxylthioxo-naphthalimides as DNA photocleavers of aroyloxyl oxygen radicals: synthesis, evaluation, and substituents' effect

BIOORG. MED. CHEM. LETT. -2004-4755: Novel fluoro- and hydroxyl-containing jasmonate derivatives as highly efficient elicitors in suspension cultures of Taxus chinensis 

BIOORG. MED. CHEM. LETT. -2006-803: Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease 

BIOORG. MED. CHEM. -2006-2935: Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding 

BIOORG. MED. CHEM. -2006-23: Eliminating nucleic acids contaminants by hydrogen peroxide-induced free radicals during the preparation of proteins

BIOTECH. BIOENG. -2005-516: Highly efficient strategy for enhancing taxoid production by repeated elicitation with a newly synthesized jasmonate in fed- batch cultivation of Taxus chinensis cells 

BIOTECH. BIOENG. -2004-809: Novel chemically synthesized hydroxyl-containing jasmonates as powerful inducing signals for plant secondary metabolism 

BIOTECH. BIOENG. -2004-595: Novel synthetic jasmonates as highly efficient elicitors for taxoid production by suspension cultures of Taxus chinensis

BIOTECH. PROGR. -2006-331: Novel chemically synthesized salicylate derivative as an effective elicitor for inducing the biosynthesis of plant secondary metabolites 

BIOTECH. AND BIOPROCESS ENGI. -2005-162: Efficient elicitation of ginsenoside biosynthesis in cell cultures of Panax notoginseng by using self-chemically-synthesized jasmonates 

CHEM. RES. CHINESE UNIV.-2010-981:Reductive Metabolism of Nitroaromatic Compounds by Various Liver Microsomes

BIOCHEM. ENGINEERING. J. -2006-23: Eliminating nucleic acids contaminants by hydrogen peroxide-induced free radicals during the preparation of proteins